Will Kenyan Men Use them? Male birth control pill one step closer to reality, researchers say
Birth control pills have solely been used by women over the years but a male version that is both safe and effective may be on the horizon, a new study shows.
Dimethandrolone undecanoate (DMAU) effectively reduced testosterone and other hormone levels responsible for sperm production without any serious side effects, according to Dr. Stephanie Page, an endocrinologist at the University of Washington School of Medicine and a lead author of the study.
“Our goal — and everyone’s goal in this field — is to develop a method for men that has minimal side effects, and the holy grail would be to develop something that also has a health benefit for men,” she said.
The results of the study were recently presented at the annual Endocrine Society meeting in Chicago.
There are a number of birth control options for women, including hormone-based pills, injections and intrauterine devices. However, the menu of options is much smaller for men.
“The only options currently available for men are vasectomy, condoms and coitus interruptus,” Page said. “Forty percent of pregnancies worldwide are unplanned, so there’s clearly an unmet need for novel contraceptives, and men have very few options.”
The new study relied on 83 men between the ages of 18 and 50 who were randomly assigned to either a control group or one of three treatment groups. Each treatment group received a different dosage of the drug: 100, 200 or 400 milligrams.
The researchers found that, after taking the drug for 28 days, testosterone in the blood dropped to castrate levels for all three doses.
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“Castrate levels” refers to the target range of testosterone in the blood after chemical or surgical castration and is usually defined as 50 nanograms per deciliter.
Low Testosterone Levels
The group given 400 milligrams also saw a significant reduction in LH and FSH, two hormones that help regulate testosterone and sperm production by the testes.
“Normal testosterone in a man is anywhere from 350 to 1,100 nanograms per deciliter,” said Dr. Seth Cohen, an assistant professor of urology at NYU Langone Health, who was not involved in the study. “And they got these guys down to 13 nanograms per deciliter.”
A testosterone level this low would typically be found only in prepubescent boys and girls, not adult men, according to the Mayo Clinic.
But due to the study’s small sample size, more research is needed to evaluate the potential side effects of the drug in the general population, Cohen said.
“Nine participants had decreased libido, which is not small,” he said. “When you put that on a large, multimillion-person basis, you have a huge portion of men running around with very low libido.”
Tricking the body
Finding a male birth control pill has been a medical goal since at least the 1950s, when scientists first began developing hormonal birth control options.
Though “the pill” eventually gained popularity among women, hormonal birth control options for men never really took off, according to Page.
“People have been working on male hormonal contraception for 40 to 50 years,” she said. “There are ways of delivering male contraceptives with long-acting implants and injections, but men are interested in having an oral pill available, and the work we presented here is a step forward.”
The substance used in the study, DMAU, has properties similar to both androgens, such as testosterone, and progestins, such as progesterone.
Prevent Side Effects
Consequently, it can “trick” the body into thinking that testosterone levels are adequate, inhibiting the hormonal pathways that ultimately lead to the production of sperm, according to Cohen.
The drug’s androgen-like properties are also supposed to prevent side effects typically associated with low testosterone levels, Page said.
“If you simply took the men’s testosterone down to these low levels, they would absolutely have side effects. They would have hot flashes just like women do when they go through menopause, and they would have marked changes in sexual desire and function,” she said.
“The very important point here is that despite having those low levels of testosterone, the steroid that is given in this prototyped male pill provides the androgen activity in the man in all the other parts of their body,” Page added.